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Zwitterionic hyperbranched polyester functionalized cardiovascular stent and its biocompatibility.

Xiaobo Wang1, Jingjing Miao1, Xiaobao Shao2

  • 1Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.

Journal of Colloid and Interface Science
|February 25, 2014
PubMed
Summary

Zwitterionic hyperbranched polyester coatings on bare metal stents improve blood compatibility. The modified stents show no adverse effects on blood cells or clotting, indicating potential for biomedical use.

Keywords:
Blood compatibilityHyperbranched polyesterZwitterion

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Bare metal stents (BMS) can trigger adverse blood reactions.
  • Improving the hemocompatibility of BMS is crucial for preventing thrombosis and restenosis.
  • Surface modification of medical devices is a key strategy in biomaterial development.

Purpose of the Study:

  • To synthesize zwitterionic hyperbranched polyester (HBPE) on BMS surfaces.
  • To evaluate the hemocompatibility of the HBPE-modified BMS.
  • To assess the potential of HBPE-coated BMS for biomedical applications.

Main Methods:

  • Surface-initiated atom transfer radical polymerization (SI-ATRP) was used to graft HBPE onto BMS.
  • Hemocompatibility was assessed through platelet adhesion tests, hemolysis assays, red blood cell (RBC) morphology, coagulation tests, and plasma recalcification time (PRT) assays.
  • Complement activation, platelet activation, and cytotoxicity were also investigated.

Main Results:

  • The HBPE-modified BMS surface exhibited significantly reduced platelet adhesion.
  • No significant hemolysis or morphological changes in RBCs were observed.
  • The modified BMS did not induce complement or platelet activation.
  • No cytotoxicity was detected for the modified BMS.

Conclusions:

  • Zwitterionic HBPE coating renders BMS surfaces highly blood compatible.
  • The modified BMS demonstrates excellent hemocompatibility and lack of cytotoxicity.
  • These findings suggest promising potential for HBPE-modified BMS in biomedical applications.