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Histamine liberation and aggregation of rabbit blood platelets treated with beta-adrenoceptor blocking drugs
1Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Czechoslovakia.
The liberation of histamine from rabbit blood platelets during aggregation as well as the effect of propranolol and atenolol on this process was investigated. Thrombin, but not ADP, liberated histamine from platelets in a dose-dependent manner. This liberation was influenced by beta-adrenoceptor blocking drugs and some modes of action are discussed.
The liberation of histamine from rabbit blood platelets during aggregation as well as the effect of propranolol and atenolol on this process was investigated. Thrombin, but not ADP, liberated histamine from platelets in a dose-dependent manner. This liberation was influenced by beta-adrenoceptor blocking drugs and some modes of action are discussed.