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Related Experiment Video

Updated: May 2, 2026

Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining
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Quantitative Examination of Antibiotic Susceptibility of Neisseria gonorrhoeae Aggregates Using ATP-utilization Commercial Assays and Live/Dead Staining

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Gonorrhoea.

Sarah Creighton1

  • 1Department of Sexual Health, Homerton University Hospital, London, UK.

BMJ Clinical Evidence
|February 25, 2014
PubMed
Summary
This summary is machine-generated.

This systematic review examines antibiotic treatments for gonorrhoea, including dual therapy for co-infections. Evidence on effectiveness and safety of various regimens is presented for uncomplicated and disseminated infections.

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Gonorrhoea diagnosis rates are high in young adults (20-24 years) in the UK.
  • Antimicrobial resistance is a growing concern, affecting over 25% of gonorrhoea isolates.
  • Co-infection with Chlamydia trachomatis is common, occurring in 10-40% of gonorrhoea cases.

Purpose of the Study:

  • To systematically review treatments for uncomplicated gonorrhoea in men and women (pregnant and non-pregnant).
  • To evaluate treatments for disseminated gonococcal infection.
  • To assess the effectiveness of dual treatment for gonorrhoea and chlamydia co-infections.

Main Methods:

  • Systematic literature review including Medline, Embase, and Cochrane Library up to September 2013.
  • Inclusion of 7 studies meeting predefined criteria.
  • GRADE evaluation of evidence quality for interventions.

Main Results:

  • Seven studies met the inclusion criteria for the review.
  • GRADE methodology was used to assess the quality of evidence for various interventions.

Conclusions:

  • The review synthesizes information on the effectiveness and safety of antibiotic regimens for gonorrhoea.
  • Interventions evaluated include dual treatment, multiple-dose, and single-dose antibiotic regimens.