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Role of calprotectin in cardiometabolic diseases

Peter Kruzliak1, Jan Novák2, Miroslav Novák3

  • 1Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne' University Hospital Brno, Brno, Czech Republic; Institute of Normal and Pathological Physiology and Centre of Excellence for Regulatory Role of Nitric Oxide in Civilisation Diseases, Slovak Academy of Sciences, Bratislava, Slovak Republic.

Cytokine & Growth Factor Reviews
|February 25, 2014
PubMed

Insights

Calprotectin, a marker of inflammation, shows promise as a prognostic factor for cardiovascular and cardiometabolic diseases. This peptide may help predict the progression of atherosclerosis and related conditions.

Area of Science:

  • Biochemistry
  • Immunology
  • Cardiology

Background:

  • Calprotectin is a peptide secreted by neutrophils and monocytes during inflammation.
  • It is a known biomarker for inflammatory bowel diseases.
  • Cardiovascular and cardiometabolic diseases are linked to low-grade chronic inflammation.

Purpose of the Study:

  • To review the role of calprotectin in cardiometabolic risk.
  • To explore calprotectin's potential as a prognostic factor for cardiovascular diseases.
  • To highlight calprotectin's utility in diagnosing and stratifying risk for cardiometabolic conditions.

Main Methods:

  • Literature review of studies on calprotectin and inflammation.
  • Analysis of research linking calprotectin to cardiovascular and cardiometabolic diseases.
  • Synthesis of evidence regarding calprotectin's diagnostic and prognostic value.

Main Results:

  • Calprotectin is involved in inflammatory processes.
  • Emerging evidence suggests calprotectin as a prognostic marker for cardiovascular diseases.
  • Calprotectin may predict the course of atherosclerosis, coronary artery disease, and acute coronary syndromes.

Conclusions:

  • Calprotectin's role extends beyond inflammatory bowel diseases.
  • It holds significant potential as a prognostic biomarker for cardiometabolic risk.
  • Further research is warranted to fully establish calprotectin's clinical utility in cardiology.

Keywords:
CalprotectinCardiovascular diseasesMetabolic diseasesMyocardial infarctionObesity

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