Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoreactive substance P in the human ovary.

D H Barad1, K J Ryan, K Elkind-Hirsch

  • 1Laboratory of Human Reproduction and Reproductive Biology, Harvard Medical School, Boston, Massachusetts.

American Journal of Obstetrics and Gynecology
|July 1, 1988
PubMed
Summary

Substance P, a neuropeptide, has been identified in normal human ovaries for the first time. This finding suggests substance P may play a role in regulating ovarian function.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endovascular coil embolization compared to surgical ligation of the uterine artery in a non-human primate model in a model of preeclampsia.

Laboratory animal research·2026
Same author

Final survival results from the PENELOPE-B trial investigating palbociclib versus placebo for patients with high-risk HR+/HER2- breast cancer and residual disease after neoadjuvant chemotherapy.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Birthweight in a non-human primate model of placental ischaemia.

Pregnancy hypertension·2024
Same author

Palbociclib combined with endocrine treatment in hormone receptor-positive, HER2-negative breast cancer patients with high relapse risk after neoadjuvant chemotherapy: subgroup analyses of premenopausal patients in PENELOPE-B.

ESMO open·2024
Same author

Treatment Outcomes of Stereotactic Ablative Body Radiotherapy on Extra-cranial Oligometastatic and Oligoprogressive Breast Cancer: Mature Results from a Single Institution Experience.

Clinical oncology (Royal College of Radiologists (Great Britain))·2024
Same author

Delivery outcomes as a result of snoring as determined by standard sleep surveys.

Obstetric medicine·2022

Area of Science:

  • Reproductive biology
  • Neuroendocrinology
  • Gynecology

Background:

  • Substance P, a neuropeptide, is known to exist in nonhuman ovaries.
  • Its presence in normal human ovarian tissue has not been previously documented.

Purpose of the Study:

  • To investigate the presence and distribution of immunoreactive substance P in normal human ovarian tissue.
  • To explore the potential role of substance P in modulating ovarian function.

Main Methods:

  • Analysis of ovarian surgical specimens from 30 women.
  • Quantification of immunoreactive substance P using radioimmunoassay.

Main Results:

  • Immunoreactive substance P was successfully identified in human ovarian extracts.

Related Experiment Videos

  • Concentrations varied by ovarian structure: theca and stroma had higher levels than corpora lutea and tunica albuginea.
  • Large follicles showed lower substance P concentrations compared to small follicles.

    • Conclusions:

    • The neuropeptide substance P is present in normal human ovaries.
    • Substance P may function as a modulator of human ovarian activity.