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Related Experiment Videos

Systemic candidiasis and pneumonia in preterm infants.

H L Loke1, I Verber, W Szymonowicz

  • 1Department of Paediatrics, Monash Medical Centre, Clayton, Victoria, Australia.

Australian Paediatric Journal
|April 1, 1988
PubMed
Summary

Systemic candidiasis affects preterm infants, particularly those with very low birthweight. Early diagnosis and antifungal treatment lead to favorable outcomes, despite potential complications.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Pediatric Critical Care

Background:

  • Systemic candidiasis is a serious fungal infection in preterm infants.
  • Very low birthweight infants are particularly vulnerable to invasive fungal infections.
  • Understanding the clinical presentation and outcomes is crucial for timely intervention.

Purpose of the Study:

  • To report on the clinical characteristics, diagnosis, and outcomes of systemic candidiasis in preterm infants.
  • To evaluate the effectiveness and safety of antifungal therapy in this population.
  • To emphasize the importance of early detection and management.

Main Methods:

  • Retrospective case series of 22 preterm infants with systemic candidiasis.
  • Analysis of clinical features, diagnostic methods, treatment strategies, and patient outcomes.
  • Comparison of laboratory findings with bacterial infections.

Main Results:

  • Fifteen infants had positive blood, CSF, or urine cultures; seven had Candida pneumonia.
  • Clinical signs included instability, respiratory decline, and necrotizing enterocolitis-like symptoms.
  • Mortality was 18%, with an 18% impairment rate among survivors; treatment delays were noted.

Conclusions:

  • Systemic candidiasis requires a high index of suspicion in very low birthweight preterm infants.
  • Early recognition and prompt antifungal therapy (amphotericin B, 5-flucytosine) are associated with favorable short- and long-term outcomes.
  • Effective and safe antifungal treatment is possible, with manageable complications.

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