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Brain-derived neurotrophic factor in the airways.

Y S Prakash1, Richard J Martin2

  • 1Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, MN 55905, United States; Department of Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN 55905, United States.

Pharmacology & Therapeutics
|February 25, 2014
PubMed
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Brain-derived neurotrophic factor (BDNF) plays a crucial role in lung development and function. Altered BDNF levels are linked to respiratory diseases like asthma, suggesting its therapeutic potential.

Keywords:
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Area of Science:

  • Neuroscience
  • Pulmonology
  • Molecular Biology

Background:

  • Neurotrophins, including brain-derived neurotrophic factor (BDNF), are increasingly recognized for their roles beyond the nervous system.
  • Expression of BDNF and its receptors in lung tissue suggests involvement in respiratory physiology and disease.
  • Altered BDNF levels are observed in conditions such as asthma, sinusitis, influenza, and lung cancer.

Purpose of the Study:

  • To review the significance of BDNF in early airway and lung development.
  • To explore BDNF's role in neurogenic control of airway tone and allergic inflammation.
  • To discuss local BDNF production by airway cells and its contribution to airway hyperreactivity and remodeling.

Main Methods:

  • This review synthesizes existing literature on BDNF in the respiratory system.
  • Focuses on developmental, physiological, and pathophysiological aspects.
  • Examines clinical data and emerging research findings.

Main Results:

  • BDNF is critical for normal lung development and function, with disruptions linked to prematurity, inflammation, and infection.
  • Airway-derived BDNF influences neurogenic control of airway tone and allergic responses.
  • Local BDNF production by airway cells contributes to airway structure, function, hyperreactivity, and remodeling in asthma.

Conclusions:

  • BDNF has multifaceted roles in airway development, function, and disease.
  • BDNF signaling is implicated in asthma pathogenesis, including airway hyperreactivity and remodeling.
  • BDNF presents a promising therapeutic target for various airway diseases.