The development of an animal model for TDI asthma

Although TDI asthma has been recognised for more than twenty years, the mechanism of the reaction is still highly controversial. To assist in elucidation of the mechanism, an animal model has been developed which displays many of the characteristics of the response including immediate- and late-onset pulmonary reactions, cytophilic antibody production, and dermal sensitivity. This communication traces the development of the guinea pig model, describes the rationale behind its methodology, and presents evidence for validation of the model. Concepts derived from the model regarding factors promoting sensitization are discussed.