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Molecular epidemiology of Aleutian mink disease virus in China

Zhenjun Wang1, Wei Wu1, Bo Hu1

  • 1Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, China.

Virus Research
|February 25, 2014
PubMed

Insights

Aleutian mink disease virus (AMDV) molecular epidemiology in China reveals independent introductions of two AMDV lineages. Both indigenous and imported AMDV strains are prevalent across major mink farming regions.

Area of Science:

  • Veterinary Virology
  • Molecular Epidemiology
  • Immunology

Background:

  • Aleutian mink disease (AMD) is a severe immune-complex-mediated disease in mink.
  • The disease is caused by the Aleutian mink disease virus (AMDV).
  • Understanding AMDV molecular epidemiology is crucial for disease control in China's mink population.

Purpose of the Study:

  • To investigate the molecular epidemiology of Aleutian mink disease virus (AMDV) in China.
  • To analyze the genetic diversity and phylogenetic relationships of AMDV strains circulating in Chinese mink farms.

Main Methods:

  • Collection of 420 mink serum samples from five major mink-farming provinces in China.
  • Detection of AMDV antibodies using counterimmunoelectrophoresis (CIEP).
  • Amplification, sequencing, and phylogenetic analysis of the VP2 gene from 23 positive samples using UPGMA.

Main Results:

  • Phylogenetic analysis of AMDV VP2 gene sequences revealed five distinct groups (I-VI), with four containing Chinese strains.
  • The study identified two independent introductions of AMDV lineages into China.
  • Over 70% of Chinese isolates clustered into two main groups, indicating prevalent strains.

Conclusions:

  • AMDV strains in China exhibit diverse origins, with evidence of both indigenous and imported strains.
  • The geographical distribution of AMDV strains is not solely determined by origin.
  • Findings highlight the complex epidemiological landscape of AMDV in Chinese mink populations.
Keywords:
Aleutian mink disease virusMolecular epidemiologyPhylogenetic analysisVP2

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