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Monoclonal anti-Thy 1 antibody (OX7) is axonally transported in rat nervous system
1Neurology Department, Vanderbilt University, Nashville, TN 37212.
Monoclonal anti-Thy 1 antibody (OX7) was pressure microinjected into vagus nerve, tongue or caudate nucleus of rats. Indirect anti-IgG immunoperoxidase staining showed that OX7 was axonally transported antero- and/or retrogradely from all injection sites. Histological examination and behavioral observations did not reveal neurotoxicity from these single OX7 injections. We conclude OX7 may prove useful as a carrier for selectively targeting molecules at neurons via endocytosis and axonal transport.
Monoclonal anti-Thy 1 antibody (OX7) was pressure microinjected into vagus nerve, tongue or caudate nucleus of rats. Indirect anti-IgG immunoperoxidase staining showed that OX7 was axonally transported antero- and/or retrogradely from all injection sites. Histological examination and behavioral observations did not reveal neurotoxicity from these single OX7 injections. We conclude OX7 may prove useful as a carrier for selectively targeting molecules at neurons via endocytosis and axonal transport.