Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metal-Ligand Bonds02:51

Metal-Ligand Bonds

19.3K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
19.3K
Ligand Binding Sites02:40

Ligand Binding Sites

11.9K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
11.9K
Complexation Equilibria: The Chelate Effect01:19

Complexation Equilibria: The Chelate Effect

1.7K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.7K
Protein-protein Interfaces02:04

Protein-protein Interfaces

12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
Complexometric Titration: Ligands00:43

Complexometric Titration: Ligands

2.5K
Different monodentate and polydentate ligands are used as complexing agents in complexometric titration reactions. The formation of complexes by mono- and bidentate ligands involves two or more intermediate steps, limiting their use as complexing agents. In comparison, polydentate ligands can form complexes with metal ions in a single-step process, facilitating sharper end points. This means polydentate ligands, such as amino carboxylic acid derivatives, are most commonly employed in...
2.5K
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

4.1K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Imidazol-2-ylidene-Based NCCN Ligands for Chiral-at-Iron Catalysis.

Organometallics·2026
Same author

Asymmetric Iron-Catalyzed Vicinal C(sp<sup>3</sup>)─H Diamination of Carboxylic Acids.

Angewandte Chemie (International ed. in English)·2026
Same author

An Achiral Tetradentate Cis-α-Coordinating NCCN Ligand Gives Rise to a Configurationally Stable Chiral-at-Iron Complex for Enantioselective Catalysis.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same author

PPG-based smartphone application vs usual care for atrial fibrillation screening: A European multicenter randomized trial.

Heart rhythm·2025
Same author

Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis.

Nature communications·2025
Same author

VASA. Zeitschrift fur Gefasskrankheiten·2025

Related Experiment Video

Updated: May 2, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

9.3K

Metal complexes as structural templates for targeting proteins.

Markus Dörr1, Eric Meggers2

  • 1Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.

Current Opinion in Chemical Biology
|February 25, 2014
PubMed
Summary
This summary is machine-generated.

This review explores inert metal complexes designed as protein binders. These metal-based compounds offer unique structural roles, expanding molecular diversity beyond traditional organic chemistry for drug discovery.

More Related Videos

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.2K
Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
08:53

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

Published on: January 11, 2017

8.2K

Related Experiment Videos

Last Updated: May 2, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
14:44

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR

Published on: December 16, 2013

9.3K
Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA
10:21

Author Spotlight: Streamlining Protein Target Prediction and Validation via Molecular Docking and CETSA

Published on: February 23, 2024

3.2K
Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
08:53

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro

Published on: January 11, 2017

8.2K

Area of Science:

  • Inorganic Chemistry
  • Medicinal Chemistry
  • Structural Biology

Background:

  • Traditional drug discovery often relies on organic molecules.
  • Metal complexes offer unique structural and electronic properties.
  • Designing metal complexes for biological targets presents challenges and opportunities.

Purpose of the Study:

  • To review advances in designing inert metal complexes as protein binders.
  • To highlight the structural role of metals in organizing ligands for protein pocket complementarity.
  • To showcase the potential of metal complexes to expand chemical space for drug discovery.

Main Methods:

  • Review of recent literature on inert metal complexes.
  • Analysis of structural features of sandwich, half-sandwich, and octahedral d(6)-metal complexes.
  • Evaluation of metal complexes as scaffolds for protein binding.

Main Results:

  • Inert metal complexes can be effectively designed as protein binders.
  • The metal center plays a crucial structural role, organizing ligands for specific protein interactions.
  • Examples include various d(6)-metal complex geometries.

Conclusions:

  • Metal complexes are highly promising scaffolds for developing small-molecule protein binders.
  • These complexes complement the molecular diversity of organic chemistry.
  • They open new avenues in untapped chemical space for therapeutic applications.