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Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork

Constance Alabert1, Jimi-Carlo Bukowski-Wills2, Sung-Bau Lee1

  • 1Biotech Research and Innovation Centre (BRIC) and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

Nature Cell Biology
|February 25, 2014
PubMed
Summary

This study reveals how proteins associate with DNA during replication using nascent chromatin capture. It maps protein dynamics, identifies new replication factors, and aids understanding of genome and epigenome maintenance.

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