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Quantitative Mueller matrix fluorescence spectroscopy for precancer detection.

J Jagtap, S Chandel, N Das

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    |February 25, 2014
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    Precancerous cervical tissues show reduced fluorescence polarization effects due to collagen changes. These spectral diattenuation and polarizance metrics may aid in diagnosing cervical precancer.

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    Area of Science:

    • Biomedical Optics
    • Medical Diagnostics
    • Biochemistry

    Background:

    • Connective tissue in human cervical tissue exhibits unique fluorescence properties.
    • Collagen molecular structures in connective tissue are anisotropically organized.
    • Changes in collagen organization are associated with cervical precancer.

    Purpose of the Study:

    • To investigate quantitative fluorescence spectroscopic Mueller matrix measurements in human cervical tissue.
    • To explore the potential of fluorescence diattenuation and polarizance as diagnostic metrics for cervical precancer.

    Main Methods:

    • Quantitative fluorescence spectroscopic Mueller matrix measurements were performed on connective tissue.
    • Analysis focused on fluorescence diattenuation and polarizance parameters.
    • Control experiments confirmed findings related to collagen organization.

    Main Results:

    • Intriguing fluorescence diattenuation and polarizance effects were observed.
    • These parameters were significantly reduced in precancerous tissues compared to normal tissues.
    • Reduced parameters correlated with the loss of anisotropic collagen organization in higher grades of precancer.

    Conclusions:

    • Fluorescence spectral diattenuation and polarizance originate from anisotropic collagen structures.
    • The reduction in these parameters indicates a loss of collagen anisotropy in cervical precancer.
    • These fluorescence polarization parameters show potential as novel diagnostic metrics for cervical precancer.