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German physicist Wilhelm Röntgen (1845–1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife’s hand. Scientists worldwide quickly began their own experiments with...
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Updated: May 2, 2026

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    We developed a new single-shot method to measure X-ray absorption and phase shift using photon-counting detectors in grating interferometry. This approach accurately quantifies X-ray properties in a single exposure.

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    Area of Science:

    • Medical Imaging
    • Physics
    • Materials Science

    Background:

    • Grating interferometry is a powerful technique for X-ray imaging.
    • Quantitative phase contrast imaging requires precise measurement of X-ray absorption and phase shift.
    • Current methods can be complex and time-consuming.

    Purpose of the Study:

    • To present a novel single-shot approach for quantitative retrieval of X-ray absorption and phase shift.
    • To leverage the energy-resolving capabilities of photon-counting detectors for improved accuracy.
    • To validate the proposed method through numerical simulations.

    Main Methods:

    • Utilizing energy-resolving X-ray photon-counting detectors.
    • Developing a retrieval algorithm based on the detector's spectral information.
    • Performing numerical simulations incorporating photon shot noise.

    Main Results:

    • The single-shot approach successfully retrieves X-ray absorption and phase shift.
    • Simulations show good agreement between retrieved and theoretical values.
    • The method demonstrates robustness even with photon shot noise.

    Conclusions:

    • The proposed single-shot method is feasible for quantitative X-ray absorption and phase shift retrieval.
    • This technique offers a more efficient alternative to existing methods in grating interferometry.
    • The use of photon-counting detectors enhances the quantitative capabilities of X-ray grating interferometry.