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Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon
W Clauss1, J E Dürr, R Krattenmacher
1Institut für Veterinärphysiologie, Freie Universität Berlin, Federal Republic of Germany.
Experientia
|July 15, 1988
Abstract:
In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone.