Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Signet-ring clear-cell basal cell carcinoma.

R E Cohen¹, M T Zaim

¹Department of Pathology, Western Reserve University, Cleveland, Ohio 44106.

Journal of Cutaneous Pathology

|June 1, 1988

Summary

This study reports a rare signet-ring, clear-cell variant of basal cell carcinoma. Histopathology suggests differentiation towards outer root sheath cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prediction of thermally driven quasi-1D superionic states in carbon hydride under giant planetary conditions.

Nature communications·2026

Same author

Absence of High-Pressure Ground-State Reentrant Ferroelectricity in PbTiO_{3}.

Physical review letters·2024

Same author

Computational Screening and Stabilization of Boron-Substituted Type-I and Type-II Carbon Clathrates.

Journal of the American Chemical Society·2023

Same author

Ultrahigh-pressure disordered eight-coordinated phase of Mg<sub>2</sub>GeO<sub>4</sub>: Analogue for super-Earth mantles.

Proceedings of the National Academy of Sciences of the United States of America·2022

Same author

Measuring the melting curve of iron at super-Earth core conditions.

Science (New York, N.Y.)·2022

Same author

Thermal conductivity of Fe-Si alloys and thermal stratification in Earth's core.

Proceedings of the National Academy of Sciences of the United States of America·2021

Area of Science:

Dermatopathology
Oncology
Cell Biology

Background:

Basal cell carcinoma (BCC) exhibits diverse histopathologic variants.
These variants often reflect differentiation along squamous, follicular, eccrine, or sebaceous lines.

Observation:

A rare signet-ring, clear-cell variant of BCC was identified.
Histopathologic features included dermal nests with peripheral palisading and folliculocentric arrangement.
Tumor cells were glycogen-rich, mucin-negative, pankeratin-positive, and negative for cytokeratin, S100 protein, and CEA.

Findings:

The unique histopathologic and immunohistochemical profile supports a distinct BCC variant.
Special stains revealed glycogen-rich clear cells, differentiating it from other BCC subtypes.

Implications:

This finding expands the spectrum of known basal cell carcinoma histopathologic variants.
The proposed differentiation towards outer root sheath cells offers insights into BCC tumorigenesis.
Understanding rare variants aids in accurate diagnosis and potentially targeted therapies.

Related Experiment Videos