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Updated: May 2, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
Exploring the role of SlrR and SlrA in the SinR epigenetic switch
Joseph A Newman1, Richard J Lewis2
1Structural Genomics Consortium; Nuffield Department of Clinical Medicine; University of Oxford; Oxford, UK ; Institute for Cell and Molecular Biosciences; University of Newcastle; Newcastle upon Tyne, UK.
Bacterial Biofilms Are Becoming A Significant Societal Problem:
biofilms form dental plaque, coat ships causing biofouling, and cling onto medical instruments and implants. Understanding how these surface-bound communities are formed is crucial for the development of suitable strategies for their dispersal. At the heart of a switch that commits Bacilli and related species to form biofilms is a transcriptional regulator called SinR and its multiple antagonists. In this addendum, we discuss an alternative model to account for how one of the antagonists is regulated by controlled proteolysis.
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