Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pluronic polyol: a potential alloplastic keratorefractive material.

J P Kim1, R L Peiffer, R E Holman

  • 1Department of Ophthalmology, School of Medicine, University of North Carolina, Chapel Hill 27514.

Journal of Cataract and Refractive Surgery
|May 1, 1988
PubMed
Summary

Pluronic F108, a temperature-sensitive hydrogel, showed potential for refractive surgery by causing corneal flattening in rabbits. The material was well-tolerated, with temporary corneal thickening post-injection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hearing loss is associated with cortical thinning in cognitively normal older adults.

European journal of neurology·2020
Same author

Twelve-day medium pumping into tubular cell-laden scaffold using a lab-made PDMS connector.

European cells & materials·2019
Same author

C3d-binding Donor-specific HLA Antibody Is Associated With a High Risk of Antibody-mediated Rejection and Graft Loss in Stable Kidney Transplant Recipients: A Single-center Cohort Study.

Transplantation proceedings·2018
Same author

Is a short arm cast appropriate for stable distal radius fractures in patients older than 55 years? A randomized prospective multicentre study.

The Journal of hand surgery, European volume·2017
Same author

Self-Assembled Silica Nanostructures: Simultaneous Discrimination of Handedness, Pitch and Diameter of Helical Silica Nanotubes.

Journal of nanoscience and nanotechnology·2016
Same author

A Clinicopathological Analysis of Recurrent Gastric Cancer.

Cancer research and treatment·2015

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Corneal Surgery

Background:

  • Pluronic polyols exhibit a negative temperature coefficient of gelation, transitioning from liquid to gel with increasing temperature.
  • Alloplastic keratorefractive surgery aims to correct refractive errors using synthetic materials implanted within the cornea.

Purpose of the Study:

  • To evaluate Pluronic F108 as a potential biomaterial for alloplastic keratorefractive surgery.
  • To assess the safety and efficacy of intrastromal Pluronic F108 injection in a rabbit corneal model.

Main Methods:

  • 0.3 ml of liquid Pluronic F108 was injected into the mid-stromal corneal bed of 17 rabbits.
  • Sham-operated fellow eyes served as controls.
  • Postoperative evaluation included clinical assessment (biomicroscopy, keratometry, pachymetry) and histological analysis (light and electron microscopy) up to three months.

Related Experiment Videos

Main Results:

  • Pluronic F108 was well-tolerated by the corneal tissue.
  • A transient increase in corneal thickness was observed in both experimental and control eyes, peaking at one week.
  • The experimental group exhibited refractive flattening of approximately three diopters, while control eyes showed no refractive change.

Conclusions:

  • Pluronic F108 demonstrates potential as a safe and effective material for alloplastic keratorefractive surgery.
  • The observed refractive flattening suggests a promising therapeutic effect for correcting refractive errors.