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The role of mast cells in antigen induced arthritis in mice
M F van den Broek1, W B van den Berg, L B van de Putte
1Department of Rheumatology, University Hospital St. Radboud, Nijmegen, The Netherlands.
Abstract:
Our study was designed to investigate the role of mast cells in an experimental arthritis. We used antigen induced arthritis in mast cell deficient mice and their normal littermates for this purpose. Both the severity and chronicity of infiltrate, exudate and tissue swelling appeared to be similar when the primary arthritis was examined. Cartilage damage as a result of chronic inflammation occurred to a lesser extent in mast cell deficient mice. The flare reaction of antigen induced arthritis was significantly less vehement in mast cell deficient mice considering tissue swelling, but only tendentiously different when the exudate was scored. Our results indicate that mast cells contribute to cartilage damage and may play an enhancing role in the flare reaction of arthritis in mice.