Related Experiment Video
Updated: May 2, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
[The MAP kianase cascade. A key target for treatments in skin cancerology]
G E Piérard1, C Piérard-Franchimont2, B Leonard2
1Laboratoire LABIC, Université de Liege, France.
Abstract:
Intracellular mitogen-activated protein kinases (MAPK) form a signalling cascade of proteins involved in cell proliferation, differentiation, migration and apoptosis. They are particularly activated by some cytokines, hormones, environmental stress and in skin cancers as well. A series of pharmacological compounds targeting the MAPK cascade dramatically changes skin cancerology, at least during a transient phase of the metastatic process. Some combined treatments possibly increase the median overall survival.
Related Concept Videos
MAPK Signaling Cascades
Targeted Cancer Therapies
There are several types of targeted therapies against...
Targeted Cancer Therapies
Mitogens and the Cell Cycle
M-Cdk Drives Transition Into Mitosis
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...

