Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 2, 2026

Using Pharmacological Manipulation and High-precision Radio Telemetry to Study the Spatial Cognition in Free-ranging Animals
08:28

Using Pharmacological Manipulation and High-precision Radio Telemetry to Study the Spatial Cognition in Free-ranging Animals

Published on: November 6, 2016

6.1K

Spatial navigation: implications for animal models, drug development and human studies.

A Stuchlik1, S Kubik, K Vlcek

  • 1Department of Neurophysiology of Memory, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic. stuchlik@biomed.cas.cz.

Physiological Research
|February 26, 2014
PubMed
Summary

This study introduces novel spatial tests in dynamic environments to better model real-world navigation and memory. Findings aim to improve understanding of brain mechanisms and develop new therapies for neuropsychiatric disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Task-Specific Effects of mGlu2/3 Receptor Agonist LY379268 on MK-801-Induced Behavioral and Neural Dysfunctions in Rats.

Physiological research·2026
Same author

Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.

Physiological research·2024
Same author

Serotonin and Effort-Based Decision-Making: Dissociating Behavioral Effects of 8-OH-DPAT and PCPA.

Physiological research·2024
Same author

Chemogenetic Tools and their Use in Studies of Neuropsychiatric Disorders.

Physiological research·2024
Same author

Chemobrain in blood cancers: How chemotherapeutics interfere with the brain's structure and functionality, immune system, and metabolic functions.

Medicinal research reviews·2023
Same author

Minireview: Animal model of schizophrenia from the perspective of behavioral pharmacology: Effect of treatment on cognitive functions.

Neuroscience letters·2021

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Pharmacology

Background:

  • Spatial navigation and memory are key components of declarative memory, often studied using static animal models.
  • Real-world environments are dynamic, requiring interaction with moving objects and environments, which current models do not fully capture.

Purpose of the Study:

  • To design and implement novel spatial tests in dynamic environments to study brain mechanisms of spatial processing.
  • To bridge the gap between traditional static spatial tests and the dynamic nature of real-world navigation.
  • To translate findings into therapeutic approaches for neuropsychiatric disorders and enhance memory/behavior screening.

Main Methods:

  • Development of innovative spatial navigation tasks set within dynamic, interactive environments.

More Related Videos

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K
Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:27

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

2.6K

Related Experiment Videos

Last Updated: May 2, 2026

Using Pharmacological Manipulation and High-precision Radio Telemetry to Study the Spatial Cognition in Free-ranging Animals
08:28

Using Pharmacological Manipulation and High-precision Radio Telemetry to Study the Spatial Cognition in Free-ranging Animals

Published on: November 6, 2016

6.1K
Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function
06:17

Author Spotlight: Investigating the Effects of Mind-Body-Movement Practices on Brain Function

Published on: January 26, 2024

2.7K
Behavioral Training Procedures for Head-fixed Virtual Reality in Mice
06:27

Behavioral Training Procedures for Head-fixed Virtual Reality in Mice

Published on: September 6, 2024

2.6K
  • Integration of neuropharmacological approaches to investigate the underlying brain mechanisms.
  • Utilizing an interdisciplinary methodology combining behavioral testing and neurobiological analysis.

    • Main Results:

    • Demonstrated the feasibility of studying spatial processing in more naturalistic, dynamic settings.
    • Identified key brain mechanisms involved in spatial memory within dynamic environments.
    • Established a foundation for translating animal model findings to human cognitive functions.

    Conclusions:

    • Novel dynamic spatial tests provide a more ecologically valid model for studying spatial navigation and memory.
    • This approach facilitates a deeper understanding of the neurobiological underpinnings of spatial cognition.
    • The research paves the way for developing targeted therapeutic strategies and improved diagnostic tools for cognitive impairments.