Related Experiment Video

Updated: May 2, 2026

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia
10:37

Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia

Published on: November 25, 2022

7.4K

[Familiar Mediterranean fever in Czech Republic]

Anna Sedivá, Viktor Maňásek, Andrea Gřegořová

    Vnitrni Lekarstvi
    |February 26, 2014
    PubMed

    Insights

    Familial Mediterranean fever (FMF), an autosomal recessive disorder, is identified in Czech families without Mediterranean ancestry. Most patients are heterozygotes exhibiting typical FMF symptoms, suggesting complex inheritance patterns.

    Area of Science:

    • Genetics
    • Immunology
    • Rheumatology

    Background:

    • Familial Mediterranean fever (FMF) is a well-defined autosomal recessive autoinflammatory disease.
    • FMF predominantly affects populations from Mediterranean regions.
    • Genetic mutations in the MEFV gene are the primary cause of FMF.

    Observation:

    • This study reports on four families with genetically confirmed FMF in the Czech Republic.
    • Three of these families are geographically clustered in Moravia, Central Europe.
    • Notably, these families lack typical Mediterranean ancestry.

    Findings:

    • The majority of observed patients are heterozygotes for FMF-associated mutations.
    • These heterozygotes present with clinically typical and well-defined FMF symptoms.
    • This challenges the traditional understanding of FMF inheritance patterns.

    Implications:

    • The findings suggest that FMF may occur in non-Mediterranean populations with higher frequency than previously thought.
    • Pseudodominant inheritance or other genetic/epigenetic factors may play a role in FMF presentation.
    • Further research is needed to explore the broader genetic and environmental influences on FMF pathogenesis.

    More Related Videos

    Continuous Noninvasive Measuring of Crayfish Cardiac and Behavioral Activities06:57

    Continuous Noninvasive Measuring of Crayfish Cardiac and Behavioral Activities

    Published on: February 6, 2019

    5.7K
    Simple Detection of Primary Cilia by Immunofluorescence08:07

    Simple Detection of Primary Cilia by Immunofluorescence

    Published on: May 15, 2020

    10.7K

    Related Concept Videos

    Patterns of Fever01:26

    Patterns of Fever

    Before understanding the types and patterns of fever, it is essential to know its phases.
    4.8K
    Types of Fever01:25

    Types of Fever

    Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
    Here are the different types of fever:
    1.7K
    Methods of reducing fever01:22

    Methods of reducing fever

    The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
    Pharmacological Methods of Reducing Fever:
    1.6K
    Myocarditis II: Clinical Features and Diagnostic Tests01:27

    Myocarditis II: Clinical Features and Diagnostic Tests

    Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
    493
    Increased Body Temperature01:25

    Increased Body Temperature

    A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
    6.4K
    Arboviral Encephalitis01:25

    Arboviral Encephalitis

    Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
    59