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Updated: May 2, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
Mannosylated solid lipid nanoparticles for lung-targeted delivery of Paclitaxel
Piyush Kumar Sahu1, Deepak Kumar Mishra, Nivrati Jain
1Pharmaceutics Division, Adina Institute of Pharmaceutical Sciences , Sagar, Madhya Pradesh , India.
Objective:
The present study discusses paclitaxel (PTX)-loaded mannosylated-DSPE (Distearoyl-phosphatidyl-ethanolamine) solid lipid nanoparticles (M-SLNs) using mannose as a lectin receptor ligand conjugate for lung cancer targeting and to increase the anticancer activity of PTX against A549 lung's epithelial cancer cells.
Materials And Methods:
The PTX-SLNs were prepared by solvent injection method and mannose was conjugated to the free amine group of stearylamine. The M-SLNs obtained were characterized for their particle size, polydispersity index, zeta potential and morphology by transmission electron microscope.
Results:
The M-SLNs were spherical in shape with 254 ± 2.3 nm average size, positive zeta potential (3.27 mV), 79.4 ± 1.6 drug entrapment efficiency and showed the lower extent of drug release 40% over 48 h in vitro. Cytotoxicity study on A549 cell lines and biodistrubtion study of drug revealed that M-SLNs deliver a higher concentration of PTX as compared to PTX-SLNs in an alveolar cell site.
Discussion And Conclusion:
These results suggested that mannosylated M-SLNs are safe and potential vector for lung cancer targeting.
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