Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Synthetic Biology

Synthetic Biology

Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...

Protein Organization

Protein Organization

Protein Organization

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....

Protein Networks

Protein Networks

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Building a Healthier Workforce: The Value of Employer-Sponsored Vaccinations and Vaccination Programs in the Workplace.

Journal of occupational and environmental medicine·2026

Same author

Classifying behaviors from animal-borne cameras using machine learning: automated identification of breathing events in sea turtles.

The Journal of experimental biology·2026

Same author

"I feel better as a parent" - summer programs help support children's health behaviors and parent wellbeing.

Research square·2026

Same author

Use of Pedicled Anterolateral Thigh Flap in Revascularized Profunda Femoris Artery Following Long-term Occlusion.

Plastic and reconstructive surgery. Global open·2026

Same author

SurfaceXR: Fusing Smartwatch IMUs and Egocentric Hand Pose for Seamless Surface Interactions.

IEEE transactions on visualization and computer graphics·2026

Same author

Weight loss and physical activity after total knee replacement: Study protocol for the Healthy Living randomized controlled trial.

Osteoarthritis and cartilage open·2026

Same journal

Characterization of putative proteins encoded by variable ORFs in white spot syndrome virus genome.

BMC structural biology·2019

Same journal

Correction to: Classification of the human THAP protein family identifies an evolutionarily conserved coiled coil region.

BMC structural biology·2019

Same journal

Effect of low complexity regions within the PvMSP3α block II on the tertiary structure of the protein and implications to immune escape mechanisms.

BMC structural biology·2019

Same journal

QRNAS: software tool for refinement of nucleic acid structures.

BMC structural biology·2019

Same journal

Classification of the human THAP protein family identifies an evolutionarily conserved coiled coil region.

BMC structural biology·2019

Same journal

A new technique for predicting intrinsically disordered regions based on average distance map constructed with inter-residue average distance statistics.

BMC structural biology·2019

See all related articles

Search research articles

Related Experiment Video

Updated: May 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

The 6th Computational Structural Bioinformatics Workshop.

Jing He, Amarda Shehu, Nurit Haspel

BMC Structural Biology

|February 26, 2014

Summary

This summary is machine-generated.

This collection presents computational methods for analyzing macromolecular structures, focusing on protein-ligand binding, loop conformations, RNA structure prediction, and protein structure refinement. These advancements improve accuracy and efficiency in bioinformatics.

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Related Experiment Videos

Last Updated: May 2, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

Area of Science:

Computational structural bioinformatics
Macromolecular structure analysis and prediction

Background:

The 6th Computational Structural Bioinformatics Workshop (CSBW) highlighted challenges in analyzing macromolecular structures.
Eleven selected papers address diverse computational problems in structural biology.

Discussion:

Methods include four-body potentials for protein-ligand binding affinity.
New algorithms address protein loop conformations and RNA secondary structure prediction.
Techniques for de novo protein structure prediction and Cryo-EM image analysis are presented.

Key Insights:

A conservation and rigidity-based method identifies critical protein residues.
Refinement methods are introduced for docked multimeric proteins and large ligands.
Robotics-inspired methods elucidate protein conformational transitions and pathways.

Outlook:

Advancements enhance protein structure comparison and classification.
Improved modeling of protein-ligand interactions and conformational dynamics.
Future work will focus on integrating diverse computational approaches for complex biological systems.