Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

22.9K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
22.9K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

4.8K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
4.8K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do Alopecia Areata and Hair Colour Have a Shared Genetic Component?

Experimental dermatology·2026
Same author

Pre-Exposure Prophylaxis Adherence and HIV Self-Testing App Among Women in the South Bronx: 12-Month Usability, Acceptability, and Feasibility Study.

JMIR formative research·2026
Same author

Multicytokine-based transcriptome-wide association study for 7 inflammatory skin disorders identifies candidate causal genes in keratinocytes.

The Journal of allergy and clinical immunology·2026
Same author

Centrifuge-free separation of plasma from milliliters of whole blood for point-of-care diagnostics.

Lab on a chip·2026
Same author

Perspectives on the future of skin-prosthetic interactions.

Journal of the Royal Society, Interface·2026
Same author

Dissociable perfusion chip (DPC): perfusable microfluidic chip for single-cell screening of anti-cancer drugs in live glioblastoma explants.

Lab on a chip·2026

Related Experiment Video

Updated: May 2, 2026

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
09:54

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

Published on: April 18, 2019

13.1K

Building a microphysiological skin model from induced pluripotent stem cells.

Zongyou Guo, Claire A Higgins, Brian M Gillette

    Stem Cell Research & Therapy
    |February 26, 2014
    PubMed
    Summary

    Induced pluripotent stem cells (iPSCs) enable patient-specific disease modeling for drug discovery. This study develops a microphysiological system using iPSCs to model human skin for improved drug toxicity and efficacy analysis.

    More Related Videos

    Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
    04:37

    Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

    Published on: October 17, 2025

    3.0K
    Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
    06:30

    Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

    Published on: May 17, 2021

    4.1K

    Related Experiment Videos

    Last Updated: May 2, 2026

    Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
    09:54

    Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells

    Published on: April 18, 2019

    13.1K
    Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
    04:37

    Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

    Published on: October 17, 2025

    3.0K
    Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform
    06:30

    Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

    Published on: May 17, 2021

    4.1K

    Area of Science:

    • Biotechnology
    • Regenerative Medicine
    • Drug Discovery

    Background:

    • Induced pluripotent stem cells (iPSCs) offer potential for patient-specific disease modeling.
    • Current drug discovery faces high failure rates due to inadequate preclinical models.
    • Existing models often fail to represent complex tissue interactions and systemic effects.

    Purpose of the Study:

    • To develop a microphysiological system for modeling human skin.
    • To utilize patient-specific induced pluripotent stem cells (iPSCs) for enhanced disease modeling.
    • To analyze drug interactions with human skin in a physiologically relevant context.

    Main Methods:

    • Leveraging induced pluripotent stem cells (iPSCs) for cell sourcing.
    • Developing a microphysiological system to recapitulate human skin structure and function.
    • Integrating skin models to assess drug efficacy and toxicity.

    Main Results:

    • Establishment of a functional human skin model using iPSCs.
    • Demonstration of the system's utility in analyzing drug-skin interactions.
    • Potential for improved prediction of drug responses compared to traditional methods.

    Conclusions:

    • Microphysiological systems using iPSCs represent a promising advancement for drug discovery.
    • Patient-specific iPSC-derived skin models can enhance the accuracy of toxicity and efficacy testing.
    • This approach addresses limitations in current preclinical drug evaluation by mimicking human tissue responses.