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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Asthma-IV: Diagnostic and Management01:30

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
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Allergic Reactions02:06

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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Current and future directions in pediatric allergic rhinitis.

Deborah Gentile1, Ashton Bartholow1, Erkka Valovirta2

  • 1Division of Allergy, Asthma and Immunology, Department of Medicine, Allegheny General Hospital, Pittsburgh, Pa.

The Journal of Allergy and Clinical Immunology. in Practice
|February 26, 2014
PubMed
Summary

Pediatric allergic rhinitis (AR) is increasing and impacts children's quality of life. Current treatments include avoidance and medication, with newer therapies on the horizon.

Keywords:
Allergic rhinitisAntihistaminesIntranasal corticosteroidsLeukotriene modifiersPediatricsSpecific immunotherapy

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Area of Science:

  • Pediatric Allergy and Immunology
  • Otolaryngology
  • Respiratory Medicine

Background:

  • Allergic rhinitis (AR) is a prevalent pediatric condition.
  • It significantly impairs children's sleep, learning, performance, and overall quality of life.
  • AR is linked to substantial comorbidities and complications.

Purpose of the Study:

  • To provide an updated review of pediatric allergic rhinitis.
  • Key areas covered include epidemiology, comorbidities, pathophysiology, current treatments, and future directions.

Main Methods:

  • A comprehensive literature review was conducted.
  • Information from various sources was synthesized to provide a current overview.

Main Results:

  • The prevalence of pediatric AR is rising globally.
  • This condition is associated with significant morbidity, comorbidities, and complications.
  • Current management strategies focus on allergen avoidance, pharmacotherapy, and allergen-specific immunotherapy.

Conclusions:

  • Future diagnostic advancements include microarrayed recombinant allergen testing.
  • Emerging therapies such as sublingual immunotherapy and combination products will expand treatment options.