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Multifunctional compounds: smart molecules for multifactorial diseases
1Molecular Modelling Lab (MML), Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab 147002, India.
European Journal of Medicinal Chemistry
|February 26, 2014
Summary
Multifunctional compounds (MFCs) offer a promising approach to treating complex diseases by combining multiple drugs into a single molecule. This strategy enhances efficacy and simplifies treatment regimens.
Area of Science:
- Medicinal Chemistry
- Drug Discovery
- Pharmacology
Background:
- Multifunctional compounds (MFCs) are hybrid or chimeric drugs combining multiple pharmacophores.
- MFCs elicit multiple pharmacological actions, addressing multifactorial diseases effectively.
- Recent research highlights MFC development for CNS disorders and cancers.
Purpose of the Study:
- To review the design and development strategies of MFCs.
- To provide insights into MFCs as potential treatments for multifactorial diseases.
- To highlight successful MFC candidates and ongoing research.
Main Methods:
- Review of recent scientific literature on MFCs.
- Analysis of successful MFC examples in CNS disorders and cancer treatment.
- Discussion of compounds derived from natural products and existing drugs.
Main Results:
- Successful MFCs like ziprasidone, duloxetine, sunitinib, and lapatinib are identified.
- Numerous MFCs derived from compounds like berberine, curcumin, and NSAIDs are under investigation.
- MFCs offer advantages such as reduced molecularity and improved pharmacokinetics.
Conclusions:
- MFCs represent a significant advancement in treating complex, multifactorial diseases.
- Strategic design of MFCs can lead to enhanced therapeutic effects and simplified treatment.
- Continued research into MFCs holds great promise for future drug development.
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