Bijective transformation circular codes and nucleotide exchanging RNA transcription

Area of Science:

• Genetics
• Molecular Biology
• Bioinformatics

Background:

• The C(3) self-complementary circular code X (framing code) is crucial for reading frame retrieval and maintenance in prokaryotic and eukaryotic genes.
• Mitochondrial RNAs exhibit nucleotide exchanges during transcription, suggesting alternative RNA coding mechanisms.

Purpose of the Study:

• To investigate 23 bijective transformation codes (ΠX) of the circular code X.
• To determine if these codes can facilitate nucleotide-exchanging RNA transcription.
• To explore correlations between code properties and biological relevance.

Main Methods:

• Analysis of 23 bijective transformation codes (ΠX) derived from the circular code X.
• Evaluation of Reading Frame Retrieval (RFR) probability for each ΠX.
• Correlation analysis with biological properties: EST database RNA counts, polymerization rates, amino acid coding, and amino acid chirality.

Main Results:

• The 23 bijective transformation codes (ΠX) are C(3) trinucleotide circular codes, with seven being self-complementary.
• Significant correlations were found between RFR probability and biological properties of ΠX.
• These properties include RNA counts, polymerization rates, and amino acid chirality.

Conclusions:

• The circular code X and its bijective transformations (ΠX) likely play a role in both regular and nucleotide-exchanging RNA transcription.
• The RFR of X and its transformations, linked to amino acid chirality, may have influenced the evolution of the genetic code machinery.