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The stomach cancer pooling (StoP) project: study design and presentation.
Claudio Pelucchi1, Nuno Lunet, Stefania Boccia
1aDepartment of Epidemiology, IRCCS - Istituto di Ricerche Farmacologiche Mario Negri bDepartment of Clinical Sciences and Community Health, University of Milan, Milan cSection of Hygiene, Institute of Public Health, Università Cattolica del Sacro Cuore dIRCCS San Raffaele Pisana, Rome, Italy eInstitute of Public Health, University of Porto (ISPUP) fDepartment of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal gDepartment of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California hThe Tisch Cancer Institute and Institute for Translational Epidemiology, Mount Sinai School of Medicine, New York iMemorial Sloan Kettering Cancer Centre, Rockville Centre jDepartment of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, New York kDepartment of Epidemiology, Harvard School of Public Health, Boston, Massachusetts lPenn State College of Medicine, Hershey, Pennsylvania, USA mCancer Epidemiology Unit, Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland nDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka oDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan pScience Integration Division, Social Determinants and Science Integration Directorate, Public Health Agency of Canada qDepartment of Epidemiology and Community Health, University of Ottawa, Ottawa, Ontario rAboriginal and Global Health Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada sDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran Universities of Medical Sciences, Tehran tDepartment of Community Medicine, Ardabil University of Medical Sciences, Ardabil, Iran uInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgo
The Stomach cancer Pooling (StoP) Project is a large consortium investigating gastric cancer causes. This project pools data to identify lifestyle and genetic risk factors for better prevention strategies.
Area of Science:
- Epidemiology
- Oncology
- Genetics
Background:
- Gastric cancer is a leading cause of cancer mortality globally, affecting approximately one million individuals annually.
- Understanding gastric cancer etiology is crucial for primary prevention beyond Helicobacter pylori eradication.
- Research in high-income countries is limited due to lower incidence rates.
Purpose of the Study:
- To investigate the role of lifestyle and genetic factors in gastric cancer etiology.
- To identify novel targets for primary prevention of gastric cancer.
- To analyze risk patterns across different gastric cancer subtypes and subsites.
Main Methods:
- The Stomach cancer Pooling (StoP) Project is a consortium of 22 epidemiological studies.
- Pooled analysis of individual-level data from over 9000 cases and 23 000 controls.
- Inclusion of data from Asia, Europe, and North America, with biological samples available from 12 studies.
Main Results:
- The StoP Project has aggregated data from 20 participating studies, comprising a substantial dataset.
- The dataset includes diverse demographics: 40% Asian, 43% European, 17% North American; 34% female, 66% male; median age 61.
- Study designs include population-based, hospital-based, and nested case-control studies.
Conclusions:
- The large-scale StoP Project data enables precise quantification of risk factors, including rare habits.
- The consortium will explore subgroup associations and interactions between environmental and genetic factors.
- Analysis by histotype and subsite will reveal distinct etiological characteristics and risk patterns.
