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Pituitary adenomas in Cushing's disease: do they arise from the intermediate lobe?
C Raffel1, J E Boggan, L F Eng
1Department of Neurological Surgery, School of Medicine, University of California, San Francisco.
Surgical Neurology
|August 1, 1988
Abstract:
Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.