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Association of P wave dispersion and left ventricular diastolic dysfunction in non-dipper and dipper hypertensive

Aydın Rodi Tosu1, Şerafettin Demir, Yüksel Kaya

  • 1Clinic of Cardiology, Van Education and Research Hospital; Van-Turkey. demirkardiyoloji@hotmail.com.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|February 26, 2014
PubMed

Insights

P wave dispersion is elevated in non-dipper hypertension patients, correlating with left ventricular dysfunction. This study highlights differences in cardiac electrical activity and function between dipper and non-dipper hypertensive individuals.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Electrophysiology

Background:

  • Hypertension is a major risk factor for cardiovascular events.
  • Diurnal blood pressure variations, categorized as dipper and non-dipper patterns, are associated with differential cardiovascular risk.
  • P wave dispersion (PWD) on electrocardiography reflects atrial electrical heterogeneity and has been linked to cardiovascular disease.

Purpose of the Study:

  • To investigate the correlation between P wave dispersion and left ventricular diastolic function in patients with dipper and non-dipper hypertension.
  • To assess if P wave dispersion differs between dipper and non-dipper hypertensive patients and correlates with cardiac structural and functional parameters.

Main Methods:

  • An observational cross-sectional study included 80 patients with dipper and non-dipper hypertension and 40 controls.
  • P wave dispersion was measured via electrocardiography.
  • Left ventricular ejection fraction, diastolic parameters (E/A rate, deceleration time, isovolumetric relaxation time), and cardiac structure were assessed using echocardiography.

Main Results:

  • P wave dispersion was significantly higher in non-dipper hypertensive patients compared to dipper hypertensive patients (p<0.001).
  • P wave dispersion showed a moderate but significant correlation with left ventricular mass index, interventricular septum thickness, isovolumetric relaxation time, and deceleration time.
  • Pmax duration was higher and Pmin duration was lower in non-dippers.

Conclusions:

  • Non-dipper hypertensive patients exhibit increased P wave dispersion compared to dipper hypertensive patients.
  • P wave dispersion is associated with left ventricular dysfunction in both dipper and non-dipper hypertensive individuals, suggesting its role as a potential biomarker.
Abstract

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