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Updated: May 2, 2026
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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
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Radiation therapy for recalcitrant pyoderma gangrenosum.
I A Rumeileh1, C Furlan, E Minatel
1Department of Radiation Oncology Centro di Riferimento Oncologico Aviano, Pordenone, Italy - cfurlan@cro.it.
Summary
Localized radiation therapy offers a new treatment option for pyoderma gangrenosum when immunosuppression fails. This approach provides effective palliation with minimal side effects for refractory cases.
Area of Science:
- Dermatology
- Oncology
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis often linked to systemic conditions.
- Standard treatments include topical therapies and systemic immunosuppression.
Observation:
- A 32-year-old female patient with extensive, recalcitrant PG showed no improvement with immunosuppressive measures.
- The patient was undergoing radiation therapy.
Findings:
- Localized radiation therapy resulted in a favorable treatment outcome for the patient's refractory PG.
- The therapy was well-tolerated, with only mild side effects observed in the irradiated areas.
Implications:
- Localized radiation therapy presents a potential effective palliative treatment for refractory pyoderma gangrenosum.
- This modality may be suitable for patients unable to tolerate aggressive systemic immunosuppression.
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