Related Experiment Video

Updated: May 2, 2026

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

7.6K

Human bocavirus respiratory infection in infants in Córdoba, Argentina

Laura Moreno1, Leticia Eguizábal1, Lucía María Ghietto2

  • 1Cátedra de Clínica Pediátrica, FCM, UNC.

Archivos Argentinos De Pediatria
|February 26, 2014
PubMed

Insights

Human bocavirus (HBoV) was found in 6.8% of children hospitalized with acute respiratory infection (ARI). Most HBoV cases presented as pneumonia, with no severe outcomes or complications at discharge.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Respiratory Medicine

Background:

  • Human bocavirus (HBoV) is a potential cause of acute respiratory infection (ARI) in children, but its clinical features remain unclear.
  • Previous studies suggest a variable prevalence of HBoV in pediatric ARI cases, ranging from 0.9% to 33%.

Purpose of the Study:

  • To determine the prevalence of HBoV in hospitalized children with ARI.
  • To describe the clinical characteristics of HBoV-infected children, focusing on cases without co-infections.

Main Methods:

  • A total of 222 children under 2 years old hospitalized with ARI were screened for HBoV using traditional PCR.
  • Nasal secretions were collected, and demographic, clinical, and radiological data were recorded for all participants.
  • Co-infections were identified through clinical data and laboratory results.

Main Results:

  • HBoV was detected in 15 out of 222 children (6.8% prevalence).
  • The median age of HBoV-positive children was 3.5 months; 7 out of 15 cases had co-infections with other respiratory viruses or bacteria.
  • Among HBoV cases without co-infection (8 cases), pneumonia was the predominant diagnosis (5/8), with most requiring oxygen therapy and bronchodilators.

Conclusions:

  • HBoV was identified in 6.8% of hospitalized children with ARI, with pneumonia being the most common diagnosis.
  • HBoV infections in this cohort did not present with severe cases or complications upon discharge.
  • Further research is needed to fully elucidate the clinical spectrum of HBoV in pediatric respiratory infections.
Abstract

More Related Videos

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

16.3K
Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment08:34

Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment

Published on: March 2, 2016

7.1K

Related Concept Videos

Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
59
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
87
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
199
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.8K