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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Epigenetics and human obesity.

S J van Dijk1, P L Molloy1, H Varinli2

  • 1CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, North Ryde, New South Wales, Australia.

International Journal of Obesity (2005)
|February 26, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetic changes are increasingly linked to obesity, with some markers identifiable at birth. Early life environmental exposures and later lifestyle interventions can modify these epigenetic marks, potentially predicting and preventing obesity risk.

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Area of Science:

  • Epigenetics
  • Obesity Research
  • Genomic Medicine

Background:

  • Technological advances in epigenome profiling are driving research into epigenetics and obesity.
  • Early-life environmental exposures can cause lasting epigenetic alterations, increasing later obesity risk.

Purpose of the Study:

  • To systematically review studies on DNA methylation and obesity.
  • To examine the impact of interventions on methylation and obesity.
  • To introduce the EpiSCOPE research program for understanding obesity-related epigenetic changes.

Main Methods:

  • Systematic review of 46 studies (September 2008 - September 2013).
  • Investigated associations between obesity and global, site-specific, or genome-wide DNA methylation.
  • Reviewed studies on pre- and postnatal interventions impacting methylation and obesity.

Main Results:

  • No consistent evidence found for a link between global methylation and obesity.
  • Identified multiple obesity-associated differentially methylated sites, primarily in blood cells.
  • Observed methylation alterations in weight loss studies and associations between birth methylation marks and later obesity.

Conclusions:

  • Progress in epigenetics and obesity has identified potential early epigenetic markers for obesity risk.
  • Epigenetic markers identified at birth may aid in early risk prediction and targeted prevention.
  • Epigenetic marks are modifiable through in utero exposures and adult lifestyle changes, offering intervention potential.