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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Classification01:23

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
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Modified-Release Drug Delivery Systems: Influencing Factors01:20

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Modified-release drug delivery systems are designed to optimize the therapeutic effect of drugs by minimizing side effects, reducing the dosage required, and controlling drug release to align with pharmacokinetic and pharmacodynamic needs. The system depends on two key factors: the drug's release from the formulation and its movement through the body to the target site. Unlike conventional dosage forms, where absorption is the limiting step, the rate of drug release is the key determinant in...
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Polymer nanoparticle-based controlled pulmonary drug delivery.

Moritz Beck-Broichsitter1, Alexandra C Dalla-Bona, Thomas Kissel

  • 1Faculté de Pharmacie, Institut Galien, Université Paris-Sud, Châtenay-Malabry, France.

Methods in Molecular Biology (Clifton, N.J.)
|February 26, 2014
PubMed
Summary
This summary is machine-generated.

Researchers developed and tested novel biodegradable polymeric nanoparticles for controlled pulmonary drug delivery. This method allows for better understanding of drug absorption and distribution in the lungs, aiding respiratory disorder treatments.

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Area of Science:

  • Nanomedicine
  • Pulmonary Drug Delivery
  • Pharmacokinetics

Background:

  • Controlled pulmonary drug delivery is crucial for treating systemic diseases.
  • Limited data exists on drug release from colloidal formulations after lung administration.
  • Lack of methods hinders understanding of pulmonary absorption and distribution.

Purpose of the Study:

  • To describe methods for preparing and characterizing drug-loaded polymeric nanoparticles.
  • To evaluate aerosolization of nanosuspensions using a vibrating-mesh nebulizer.
  • To assess pulmonary pharmacokinetics of nanoparticles in an isolated lung model.

Main Methods:

  • Preparation and characterization of drug-loaded biodegradable, charge-modified branched polyesters.
  • Aerosolization of nanosuspensions via a vibrating-mesh nebulizer.
  • Evaluation of nanoparticle absorption and distribution in an isolated lung model.

Main Results:

  • Successful preparation and characterization of polymeric nanoparticles.
  • Effective aerosolization of nanosuspensions demonstrated.
  • Pulmonary pharmacokinetics of nanoscale drug delivery vehicles were evaluated.

Conclusions:

  • The described methodology supports the design of advanced colloids for pulmonary administration.
  • This approach aids in understanding drug absorption and distribution in the lung.
  • Contributes to the development of novel treatments for respiratory disorders.