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Customising PRESAGE® for diverse applications.

T Juang1, J Newton1, M Niebanck1

  • 1Duke University Medical Center, Durham, NC, USA.

Journal of Physics. Conference Series
|February 26, 2014
PubMed
Summary

PRESAGE® dosimeters, customizable solid radiochromic devices, show adaptable dose sensitivity and stability. Tailored formulations offer potential for diverse clinical applications, including remote and deformable dosimetry.

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Area of Science:

  • Medical Physics
  • Materials Science
  • Radiological Dosimetry

Background:

  • PRESAGE® is a solid radiochromic dosimeter composed of a polyurethane matrix, triarylmethane leuco dye, and trihalomethane initiator.
  • Dosimeter properties like sensitivity, stability, and physical characteristics can be modified by altering constituent composition and amounts.
  • Customization enables PRESAGE® to meet specific application needs, including high-dose measurements, remote monitoring, reusability, and tissue-mimicking elasticity.

Purpose of the Study:

  • To evaluate and characterize five hard, non-deformable PRESAGE® formulations and six deformable PRESAGE® formulations.
  • To assess the dose sensitivity and post-irradiation stability of these different PRESAGE® formulations.
  • To explore the potential of deformable PRESAGE® formulations for reusability and tissue-like elasticity.

Main Methods:

  • Characterization of five hard and six deformable PRESAGE® formulations.
  • Measurement of dose sensitivity for all formulations.
  • Assessment of post-irradiation stability and optical clearing properties.
  • Tensile compression testing of deformable formulations to evaluate elastic response.

Main Results:

  • Dose sensitivities ranged from 0.0029 - 0.0467 ΔOD/(Gy·cm) for hard formulations and 0.0003 - 0.0056 ΔOD/(Gy·cm) for deformable formulations.
  • Non-deformable formulations exhibited exceptional stability, suitable for remote dosimetry.
  • Deformable formulations showed potential for reusability due to strong post-irradiation optical clearing and exhibited elastic properties similar to soft tissues.

Conclusions:

  • PRESAGE® dosimeters can be customized for a broad range of clinical applications.
  • The evaluated formulations demonstrate flexibility in dose sensitivity and stability.
  • Both hard and deformable PRESAGE® formulations show promise for specific dosimetry needs in clinical settings.