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Case report: Enteral nutritional supplement as a likely cause of false-positive galactomannan testing

Tong-Yong Ng1, Mei-Ling Kang2, Ban-Hock Tan2

  • 1Department of Pathology, Singapore General Hospital, Singapore.

Medical Mycology Case Reports
|February 26, 2014
PubMed

Insights

A galactomannan (GM) test can falsely indicate invasive aspergillosis in immunocompromised patients. Enteral nutritional supplements may cause these false positives, especially in non-neutropenic patients.

Area of Science:

  • Medical Mycology
  • Clinical Diagnostics
  • Hematopoietic Stem Cell Transplantation

Background:

  • Galactomannan (GM) testing is crucial for diagnosing invasive aspergillosis in immunocompromised individuals.
  • Early detection of invasive aspergillosis improves patient outcomes.

Purpose of the Study:

  • To report a case of a false-positive GM test.
  • To identify a potential cause of false-positive GM results in a specific patient population.

Main Methods:

  • Case report of a non-neutropenic patient post-hematopoietic stem cell transplant.
  • Analysis of GM test results in the context of patient's clinical condition and nutritional support.

Main Results:

  • A false-positive GM test was observed.
  • The false positivity was presumed to be linked to enteral nutritional supplementation.

Conclusions:

  • Clinicians must consider nutritional supplements as a potential cause of false-positive GM tests.
  • Awareness is needed for accurate diagnosis in patients receiving enteral nutrition.
Keywords:
False-positiveGalactomannanNutritional supplementTransplant

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