Related Experiment Video
Updated: May 2, 2026
Establishment of a Rat Model for Intrauterine Adhesions via Dual Injury: Curettage and Infection
Published on: October 3, 2025
Effect of vitamin D on postoperative adhesion formation in a rat uterine horn adhesion model
Saynur Sarici Yilmaz1, Deniz Hizli2, Engin Yilmaz2
1Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey. saynur77@yahoo.com
Objective:
To determine the role of vitamin D for preventing or reducing postoperative adhesions.
Study Design:
The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters.
Results:
Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p < 0.05). On the other hand, no difference was detected between the groups according to the fibrosis score.
Conclusion:
Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.
