Related Experiment Video
Updated: May 2, 2026
05:05
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
1.7K
Pemphigoid gestationis with postpartum flare-up: a case report.
Asli Kucukunal1, Ilknur Altunay2, Damlanur Sakiz2
1Department of Dermatology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey. aslikucukunal@hotmail.com
The Journal of Reproductive Medicine
|February 27, 2014
Summary
Pemphigoid gestationis (PG), an autoimmune blistering disease, typically emerges in late pregnancy. This case highlights the need for a coordinated dermatologic and gynecologic approach to manage this condition and its risks.
Area of Science:
- Dermatology
- Obstetrics
- Immunology
Background:
- Pemphigoid gestationis (PG), also known as herpes gestationis, is a rare autoimmune blistering disease.
- It predominantly affects pregnant women, usually in the third trimester.
Observation:
- A case of PG is presented with diffuse blistering and pruritic urticarial plaques starting periumbilically.
- The clinical presentation caused significant maternal and fetal stress.
Findings:
- PG is associated with adverse pregnancy outcomes, including premature delivery and small-for-gestational-age infants.
- Corticosteroids are the primary treatment modality for PG.
Implications:
- A multidisciplinary approach involving dermatology and gynecology is recommended for optimal diagnosis and management.
- Early recognition and intervention can mitigate risks to both mother and fetus.
Related Concept Videos
01:20Pathophysiology of Diabetes
3.9K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.9K
01:15Transcytosis of IgG
3.4K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
3.4K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
33
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
33