Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

22.1K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
22.1K
Gene Therapy00:59

Gene Therapy

4.5K
4.5K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

3.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
3.8K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.3K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.3K
Bone Remodeling01:40

Bone Remodeling

34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-reported outcomes following operative and nonoperative management of A3 versus A4 thoracolumbar burst fractures.

Journal of neurosurgery. Spine·2026
Same author

Minimal Clinically Important Difference (MCID) and Long-Term Prospective Validation of the AO Spine PROST (Patient Reported Outcome Spine Trauma).

Global spine journal·2026
Same author

Functional Outcomes Between Surgical and Nonsurgical Treatment for Neurologically Intact Patients With Thoracolumbar Burst Fractures as Measured by the AO Spine PROST.

Spine·2026
Same author

Incomplete (A3) versus complete (A4) thoracolumbar burst fractures: results from a prospective international multicenter cohort study.

Journal of neurosurgery. Spine·2026
Same author

Canadian Spine Society: 25th Annual Scientific Conference, February 25 to 28, 2025, Fairmont Le Manoir Richelieu, La Malbaie, Charlevoix, Que., Canada.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Hounsfield unit measurements to predict odontoid fracture union in elderly patients: posthoc subgroup analysis from an international prospective comparative study.

The spine journal : official journal of the North American Spine Society·2025

Related Experiment Video

Updated: May 2, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

8.6K

Non-viral gene therapy for bone tissue engineering.

Fiona Wegman1, F Cumhur Oner, Wouter J A Dhert

  • 1a Department of Orthopaedics , UMC Utrecht , Utrecht , The Netherlands.

Biotechnology & Genetic Engineering Reviews
|February 27, 2014
PubMed
Summary
This summary is machine-generated.

Gene therapy shows promise for bone regeneration, with improved delivery systems enhancing bone formation. These advancements offer hope for future human applications in treating bone defects.

More Related Videos

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
07:14

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

819
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K

Related Experiment Videos

Last Updated: May 2, 2026

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair
09:34

Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair

Published on: September 7, 2017

8.6K
Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids
07:14

Enhanced Gene Delivery and Expression using Intraosseous Injection of Chitosan Nanoparticles Encapsulated Adenine Base Editor Plasmids

Published on: May 16, 2025

819
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Molecular Biology

Background:

  • Gene therapy is a promising approach for bone regeneration.
  • Advances in transfection agents and delivery systems have improved efficacy and reduced toxicity.
  • Current strategies include growth factor delivery, siRNA, and enzyme replacement.

Purpose of the Study:

  • To review the progress and potential of gene therapy for bone regeneration.
  • To highlight successful in vitro, ex vivo, and in vivo strategies.
  • To assess the feasibility of human application for gene-delivery strategies.

Main Methods:

  • Investigated various gene therapy vectors and delivery systems.
  • Evaluated strategies for growth factor and short interfering ribonucleic acid (siRNA) delivery.
  • Assessed enzyme replacement therapies for bone regeneration.

Main Results:

  • Improved transfection agents and delivery systems have led to successful gene therapy strategies.
  • Demonstrated increased osteogenic differentiation and bone formation in vivo.
  • Achieved reduced cytotoxicity and enhanced transfection efficiencies.

Conclusions:

  • Gene therapy holds significant potential for bone regeneration.
  • Successful in vivo outcomes suggest future clinical applicability.
  • Optimism exists for the near-term use of gene-delivery strategies in humans.