[Where does the development of new antituberculotics go? Part 2 - in vitro evaluation].

Area of Science:

• Pharmacology
• Microbiology
• Medicinal Chemistry

Background:

• This paper continues a 2012 review on antitubercular agents.
• It focuses on in vitro evaluation methods for potential tuberculosis drugs.
• The review covers information from Chemical Abstracts between 2011 and 2013.

Purpose of the Study:

• To evaluate potential antitubercular agents using in vitro methods.
• To provide researchers with a curated selection of relevant information.
• To emphasize the importance of in vitro testing for developing new tuberculosis drugs, especially against multiresistant strains.

Main Methods:

• Literature review of Chemical Abstracts from 2011-2013.
• Selection and analysis of studies reporting in vitro antitubercular activity.
• Focus on compounds tested against multiresistant strains of Mycobacterium tuberculosis.

Main Results:

• A curated selection of nearly three thousand information items was reviewed.
• Significant attention was given to compounds effective against multiresistant Mycobacterium tuberculosis strains.
• The review consolidates recent findings in the search for novel antitubercular drugs.

Conclusions:

• In vitro evaluation is a crucial initial step in the drug discovery pipeline for tuberculosis.
• Continued research and development are necessary to combat the growing threat of multidrug-resistant tuberculosis.
• This review serves as a valuable resource for researchers in the field of antitubercular drug development.