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Rationale, design, and demographic characteristics of the Handan Offspring Myopia Study
Tie Ying Gao1, Peng Zhang, Lei Li
1Handan Eye Hospital , Handan, Hebei Province , China .
Insights
The Handan Offspring Myopia Study found 23.5% myopia prevalence in rural Chinese children, with higher rates in females. Most vision impairment was correctable, offering insights into refractive errors in this population.
Area of Science:
- Ophthalmology
- Public Health
- Genetics
Background:
- Myopia is a growing public health concern globally.
- Understanding familial associations of myopia is crucial for early intervention.
- The Handan Offspring Myopia Study (HOMS) builds upon prior research in a specific Chinese population.
Purpose of the Study:
- To investigate the familial associations of myopia between parents and their offspring.
- To determine the prevalence of refractive errors and eye diseases in rural Chinese children.
Main Methods:
- A cohort of 878 children aged 6-18 years from 541 families was recruited.
- Comprehensive eye examinations included visual acuity, ocular biometry, and autorefraction.
- Retinal photography was utilized for detailed eye assessments.
Main Results:
- The prevalence of myopia was 23.5% (females 30.8%, males 16.8%).
- Low vision prevalence was 7.1% in the better eye and 10.6% in the worse eye.
- The majority of visual impairment (90.3%) was correctable.
Conclusions:
- The HOMS successfully recruited a significant portion of eligible Han Chinese offspring.
- Findings will inform strategies for managing refractive errors in rural Chinese children.
- Further analysis will elucidate genetic and environmental factors contributing to myopia.
Purpose:
The Handan Offspring Myopia Study (HOMS) aims to investigate the familial associations of myopia between parents and their offspring.
Methods:
Children aged 6-18 years, residing in 6 villages where all people aged ≥30 years had participated in The Handan Eye Study in 2006-2007, were selected for the current eye study between March and June 2010. A mobile clinic was set up in the 6 villages for comprehensive eye examinations, including visual acuity, ocular biometry, cycloplegic autorefraction and retinal photography.
Results:
Of 1238 eligible individuals, 878 children (70.2%; 52.6% male) from 541 families were recruited. Mean age of the children was 10.5 ± 2.5 years. The prevalence of myopia (spherical equivalent refraction <-0.5 diopter) was 23.5% (males 16.8%, females 30.8%). The prevalence of low vision (presenting visual acuity ≥20/400 but <20/60) in the better eye was 7.1%. A higher number of females had low vision at the time of presentation (9.2%) compared to males (5.2%, p = 0.02). The prevalence of low vision in the worse eye was 10.6% (males 6.7%, females 14.9%, p < 0.001). The majority of visual impairment in the better-seeing (56/62, 90.3%) as well as the worse-seeing (84/93, 90.3%) eye was correctable.
Conclusions:
The HOMS examined about 70% of eligible Han Chinese offspring of Handan Eye Study participants in a rural region of northern China. Results from the HOMS will provide key information about the prevalence of refractive errors and eye diseases in rural Chinese children.
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