Related Experiment Video
Updated: Aug 18, 2026

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
Published on: May 20, 2015
Expression of "cell-cycle-dependent" genes in regenerating rat liver
1Department of Tumor Biology, Institute of Oncology, Gliwice, Poland.
Abstract:
The expression of genes coding for the ATP/ADP translocase, calcyclin, ornithine decarboxylase, vimentin, proto-onc genes p53 and c-Ha-ras1 and also for two genes JE and KC with as yet unknown function was studied during regeneration of rat liver. Genes highly induced were: JE (2-8 h of regeneration), ATP/ADP translocase (8-18 h), c-Ha-ras-1 (6-48 h) and p53 (6-12 h). Vimentin and KC gene transcripts were not detectable in the first 48 h of liver regeneration, whereas ornithine decarboxylase and calcyclin gene transcripts were present at constant levels. Our findings extend the list of genes expressed at the early stages of liver regeneration.
Related Concept Videos
Negative Regulator Molecules
Mitogens and the Cell Cycle
Tissue Renewal without Stem Cells
However, failure of such a system...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

