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Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
Published on: July 3, 2020
Mycobacterium szulgai chronic multifocal osteomyelitis in an adolescent with inherited STAT1 deficiency
Oded Shamriz1, Dan Engelhard, Andrea Psorn Rajs
1From the *Department of Pediatrics; †Pediatric Infectious Diseases Unit, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel; ‡School of Primary Health Care, Monash University, Melbourne, Victoria, Australia; §Department of Microbiology, Hadassah-Hebrew University Medical Center, Ein Kerem, Jerusalem; ¶National Mycobacterium Reference Laboratory, National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel; and ‖St. Giles Laboratory of Human Genetics of Infectious Diseases, The Rockefeller University, New York, NY.
Abstract:
We report a 17-year-old patient with inherited STAT1 deficiency, who was diagnosed with Mycobacterium szulgai chronic multifocal osteomyelitis and responded well to the therapy with ethambutol, rifampicin and azithromycin. Seven other reported cases of M. szulgai osteomyelitis are reviewed. This is the first description of M. szulgai osteomyelitis in an adolescent with a primary immunodeficiency.
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