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Updated: May 2, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
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PCMdb: pancreatic cancer methylation database.

Gandharva Nagpal1, Minakshi Sharma1, Shailesh Kumar1

  • 1Bioinformatics Centre, CSIR-Institute of Microbial Technology, Chandigarh-160036, India.

Scientific Reports
|February 27, 2014
PubMed
Summary
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Researchers created the Pancreatic Cancer Methylation Database (PCMDB) to aid early pancreatic cancer detection. This resource compiles gene methylation data, supporting biomarker discovery for this aggressive malignancy.

Area of Science:

  • Oncology
  • Bioinformatics
  • Genetics

Background:

  • Pancreatic cancer is a highly aggressive malignancy with limited early detection methods.
  • The discovery of reliable biomarkers is crucial for improving patient outcomes.
  • Gene methylation patterns are increasingly recognized as potential biomarkers in cancer.

Purpose of the Study:

  • To develop a comprehensive database of gene methylation status in pancreatic cancer.
  • To facilitate the identification and validation of novel biomarkers for early pancreatic cancer detection.
  • To provide a centralized, searchable resource for researchers in the field.

Main Methods:

  • Manual compilation of gene methylation data from published scientific literature.
  • Inclusion of data from pancreatic cancer cell lines and tissue samples.

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  • Development of a user-friendly web interface for data access and analysis.

    • Main Results:

    • The Pancreatic Cancer Methylation Database (PCMDB) contains 65,907 entries for 4,342 unique genes.
    • Data includes methylation status from 88 cell lines and 3,078 tissue samples.
    • Approximately 47.22% of entries indicate high gene methylation, and 10.87% indicate low methylation.

    Conclusions:

    • The PCMDB serves as a valuable resource for pancreatic cancer research.
    • The database is expected to accelerate the discovery of new biomarkers for early detection.
    • Facilitating research into gene methylation in pancreatic cancer subtypes, particularly adenocarcinomas.