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[Vancomycin resistant Staphylococcus epidermidis caused prosthesis infection. Linezolid and rifampicin healed the

Anders Håkanson1, Inga Fröding2, Carin Ottosson3

  • 1Infektion/Venhälsan - Södersjukhuset Stockholm, Sweden Infektion/Venhälsan - Stockholm, Sweden.

Lakartidningen
|February 27, 2014
PubMed

Insights

Coagulase-negative Staphylococci cause difficult orthopedic infections. Prolonged linezolid and rifampicin treatment successfully managed a vancomycin-resistant Staphylococcus epidermidis prosthetic joint infection.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Microbiology

Background:

  • Coagulase-negative Staphylococci (CoNS) are primary pathogens in orthopedic prosthesis infections.
  • CoNS often exhibit multi-drug resistance, complicating treatment regimens.
  • Vancomycin resistance in CoNS is uncommon in Sweden, but poses a significant therapeutic challenge.

Observation:

  • Linezolid is an alternative antibiotic for CoNS infections but is typically limited to four weeks due to potential hematological side effects.
  • A patient presented with a complicated prosthetic joint infection caused by a vancomycin-resistant Staphylococcus epidermidis strain.

Findings:

  • Successful prolonged treatment was achieved using a combination of linezolid and rifampicin.
  • This regimen effectively managed the complex prosthetic joint infection.

Implications:

  • Extended linezolid and rifampicin therapy may be a viable option for challenging vancomycin-resistant CoNS prosthetic joint infections.
  • This approach could offer an alternative for patients with limited treatment options.
  • Further research into prolonged linezolid use for resistant orthopedic infections is warranted.

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