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Updated: May 2, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Comparison of short-term outcomes after carotid artery stenting according to different stent designs
Muslum Sahin1, Göksel Açar1, Birol Ozkan1
1Kartal Kosuyolu High Speciality Education and Research Hospital, Istanbul, Turkey.
Insights
Closed-cell stents show a lower incidence of ischemic stroke after carotid artery stenting (CAS) compared to open-cell designs. This suggests closed-cell stents may be preferable for patients with high embolism risk.
Area of Science:
- Cardiovascular Surgery
- Interventional Neurology
- Biomedical Engineering
Background:
- Stroke is a leading cause of death in developed nations.
- Stents are known to reduce embolism risk, but optimal stent design for periprocedural complications remains unclear.
Purpose of the Study:
- To compare the 1-month outcomes of carotid artery stenting (CAS) using open-cell versus closed-cell stent designs.
Main Methods:
- A study of 290 patients undergoing CAS, divided into open-cell (n=144) and closed-cell (n=138) stent groups.
- All patients received neuroprotection with a distal protection device.
- Outcomes assessed included major adverse cardiac and cerebrovascular events (MACCE), transient cerebral ischemia, hypotension, and stroke at 1 month.
Main Results:
- No significant difference in MACCE or transient cerebral ischemia rates between stent groups.
- Ischemic stroke incidence was significantly lower in the closed-cell stent group (0% vs. 2.77%, p=0.04).
- Periprocedural hypotension was more frequent in the closed-cell stent group (7.2% vs. 2.1%, p=0.04).
Conclusions:
- Closed-cell stents are associated with a reduced rate of ischemic stroke following CAS.
- These findings suggest closed-cell stents may be a preferred option for patients at elevated risk of embolism.
Introduction:
In the developed countries, stroke is the third most common cause of death. There are many data indicating that stents reduce the risk of embolism but there are few publications assessing whether different stent designs can influence the periprocedural complications.
Aim:
To determine the effects of open- and closed-cell stent designs on 1-month results of carotid artery stenting (CAS).
Material And Methods:
The study group consisted of 290 consecutive patients (216 men and 74 women, mean age 66.6 ±8.7 years). Neuroprotection with a distal protection device was used in all cases. The patients were divided into two groups: the open-cell stent group (n = 144) and the closed-cell stent group (n = 138). Major adverse cardiac and cerebrovascular events (MACCE) described as myocardial infarction, stroke and death within 1 month were recorded and analysed subsequently. Periprocedural hypotension and transient cerebral ischaemia at 1 month after the CAS procedure were also assessed.
Results:
We treated 290 carotid stenoses and stents were implanted in all patients. Fifteen patients (5.5%) were treated by staged CAS due to bilateral carotid artery disease. The technical success rate was 97.2%. There was no difference in the MACCE and transient cerebral ischaemia rate at 1 month between the two groups (p = 0.44 and p = 0.94, respectively). The incidence of ischaemic stroke was lower in the closed-cell stent group (2.77% vs. 0%; p = 0.04). The periprocedural rate of hypotension was higher in the closed-cell stent group (2.1% vs. 7.2%; p = 0.04).
Conclusions:
Closed-cell stents are associated with a low rate of ischaemic stroke. We think that closed-cell stents may be preferred in patients at high risk of embolism.
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