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Susceptibility-weighted imaging changes suggesting brain iron accumulation in Huntington's disease: an epiphenomenon

A Macerollo1, R Perry, M Stamelou

  • 1Sobell Department of Motor Neuroscience and Movement Disorders, Lysholm Department of Neuroradiology, National Hospital of Neurology and Neurosurgery, Institute of Neurology, University College London, London, UK.

European Journal of Neurology
|February 28, 2014
PubMed
Abstract

No abstract available in PubMed .

Keywords:
NBIAjuvenile Huntington's disease

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Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show...
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