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Published on: November 9, 2019
Formation of a hydrogen-bonded barbiturate [2]-rotaxane
Arnaud Tron1, Peter J Thornton, Mathias Rocher
1Institut des Sciences Moléculaires, CNRS UMR 5255, Univ. Bordeaux , 33405 Talence, France.
Abstract:
Interlocked structures containing the classic Hamilton barbiturate binding motif comprising two 2,6-diamidopyridine units are reported for the first time. Stable [2]-rotaxanes can be accessed either through hydrogen-bonded preorganization by a barbiturate thread followed by a Cu(+)-catalyzed "click" stoppering reaction or by a Cu(2+)-mediated Glaser homocoupling reaction.
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