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Daptomycin-loaded polymethylmethacrylate bone cement for joint arthroplasty surgery.
Yuan-Ming Hsu1, Chun-Hsing Liao, Yu-Hong Wei
1Division of Orthopaedics, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan.
Artificial Organs
|February 28, 2014
Summary
Daptomycin-loaded acrylic bone cement demonstrates effective bactericidal properties against Gram-positive organisms. This study confirms its mechanical integrity and potential for clinical use in preventing or treating bone infections.
Area of Science:
- Biomaterials Science
- Infectious Diseases
- Orthopedic Surgery
Background:
- Antibiotic-loaded acrylic bone cement is crucial for infection prophylaxis and managing infected arthroplasty.
- Daptomycin is a valuable antibiotic for treating broad-spectrum Gram-positive bacterial infections.
Purpose of the Study:
- To evaluate the bactericidal and mechanical properties of daptomycin-incorporated polymethylmethacrylate (PMMA) bone cement.
- To assess the feasibility of daptomycin-loaded acrylic bone cement (DLABC) for clinical applications.
Main Methods:
- Daptomycin was incorporated into PMMA bone cement at varying concentrations (0.5, 1, 2 g).
- Mechanical properties were tested according to ISO 5833 standards.
- Daptomycin release kinetics and antimicrobial efficacy via zone of inhibition assays were analyzed against Staphylococcus aureus, S. epidermis, E. faecalis, and E. faecium.
Main Results:
- PMMA bone cement retained compressive strength above 100 MPa after daptomycin incorporation, meeting ISO 5833 requirements.
- Daptomycin release was observed over two weeks, with higher initial release percentages at higher daptomycin concentrations.
- All DLABC formulations exhibited antimicrobial activity, with increased efficacy correlating to higher daptomycin loading.
Conclusions:
- Daptomycin-loaded acrylic bone cement maintains sufficient mechanical integrity for clinical use.
- Daptomycin can be effectively delivered locally from PMMA bone cement to combat Gram-positive osteomyelitis.
- DLABC shows promise as a prophylactic or therapeutic agent in surgical settings for Gram-positive infections.
